I don't feel reliability plays a role in newer vehicles, so I'll skip that part.
My experience is that the fords feel tighter inside and ride a little stiffer, while GM has a better comfort level inside and suspension wise.
A truck riding like a truck is what I like because it directly correlates to better handling when towing or loaded down. I prefer Fords for this reason, and have found GM vehicles to feel "squishy" and in less control of the load.
My $.02
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