LSU-SVM 93 Zyrtec(cetirizine) is the active portion of hydroxyzine. In theory yes it is a 24hr dose. In ppl per Dr can take up to 5/day. I routinely take 1 twice daily. Cetirizine doesn't work well once a day in dogs but works great twice a day. I'm sure there is a high end dose but not in any literature that I researched. Omega 3 fatty acids help also but not to the same extent as the cetirizine in my hands.
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