For a .22, I'd recommend a Ruger Mk III or a Colt Woodsman.
Check out this link to do some browsing on Gunbroker
http://www.gunbroker.com/Auction/SearchResults.aspx
If you're thinking of personal protection in any way, a .22 is not really an option. Go .380 or better.
For your price range however, I'd recommend a revolver. You can get a nice .22 revolver made by H&R for pretty cheap. I believe it's the Sportsman model. It's a neat little plinker.
Here are the search results for revolvers.
http://www.gunbroker.com/Auction/SearchResults.aspx
Hope you find a good one. - Sandy